The p53 Tumor Suppressor Protein

Paper Summary:

The paper summarizes the article "In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2" and its study of the MDM2 protein which strongly binds to, and modulates the activity of the p53 tumor suppressor protein. The paper describes the methods and testing used and posits that the methods were relative to the objective and were properly carried out. The paper therefore agrees with the conclusion reached by the article and concludes that this is indeed a promising treatment should it be proven that suppression of MDM2 activity in p53 proteins may lead to the reduction of tumors in humans and animals.

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Summary
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From the Paper:

"The main focus of the article is around the MDM2 protein which strongly binds to, and modulates the activity of the p53 tumour suppressor protein by an autoregulatory feedback loop. This is done through three mechanisms. Firstly, MDM2 binds at the p53 transactivation site and blocks its activation of transcription initiation. Secondly, it participates in the nuclear export of p53. Thirdly, it serves as a ubiquitin ligase, promoting the degradation of p53. When p53 is activated, it can bring a halt upon the cell cycle and cause apoptosis."

Sample of Sources Used:

• Lyubomir T. Vassilev, Binh T. Vu, Bradford Graves, Daisy Carvajal, Frank Podlaski, Zoran Filipovic, Norman Kong, Ursula Kammlott, Christine Lukacs, Christian Klein, Nader Fotouhi, and Emily A. Liu. 2004. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2. Science Express. Vol. 303. no. 5659, p844 - 848.

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